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  • > 产品目录 > 科研产品 > 体细胞突变PCR芯片 > 乳腺癌体细胞突变PCR芯片
    人乳腺癌体细胞突变PCR芯片适用于快速、准确的检测和研究乳腺癌的常见基因突变,包括:AKT1, APC, BRAF, CDH1, CTNNB1, HRAS, NRAS, KRAS, PIK3CA和TP53。对上述基因突变的深入研究有助于科研工作者更好的了解肿瘤的发生机制,并为临床用药提供可靠的分子机理。
    乳腺癌体细胞突变PCR芯片
     
    人乳腺癌体细胞突变PCR芯片适用于快速、准确的检测和研究乳腺癌的常见基因突变,包括:AKT1, APC, BRAF, CDH1, CTNNB1, HRAS, NRAS, KRAS, PIK3CA和TP53。对上述基因突变的深入研究有助于科研工作者更好的了解肿瘤的发生机制,并为临床用药提供可靠的分子机理。利用单个或多个体细胞突变信息检测关键信号通路异常已被广泛应用于临床研究。例如: EGFR和KRAS基因突变能够预测靶向该位点的药物治疗响应。人乳腺癌体细胞突变PCR芯片覆盖广泛,适用于乳腺癌以及含有此类突变的其他肿瘤的突变检测,并有望为临床相关疾病提供潜在药物治疗靶点。该芯片包含84个乳腺癌中最常见的,并具有重要功能和生理学意义的突变位点。突变位点主要由多种体细胞突变数据库以及经同行评阅的科学文献筛选得到,展示了超过6000例乳腺癌患者的最常见突变。

    Assay functional annotations
    AKT1: 1 Assay
    The mutation assay detects the best known AKT1 mutation, c.49G>A, p.E17K. This is a PH domain mutation that results in constitutive targeting of AKT1 to plasma membrane.
    APC: 1 Assay
    The most commonly detected APC inactivation mutations are mainly composed of truncation mutations (due to nonsense mutations and frameshift mutations) and point mutations between codons 1250 and 1578.
    BRAF: 2 Assays
    There are two major classes of BRAF mutations. One class leads to increased BRAF kinase activity, such as the p. V600E mutation. The other class leads to impaired kinase activity, such as the p.G469A mutation.
    CDH1: 3 Assays
    The top CDH1 mutations either are missense mutations or frameshift mutations that lead to C-terminal truncation and secreted E-cadherin fragments.
    CTNNB1: 1 Assay
    The most frequently detected CTNNB1/beta-catenin mutations result in abnormal signaling in the WNT signaling pathway. The mutated codons are mainly several serine/threonine residues targeted for phosphorylation by GSK-3beta.
    HRAS: 1 Assay
    The most important HRAS mutations identified in cancers occur at codons 12
    KRAS: 5 Assays
    The mutation assays include the most frequently occurring mutations in KRAS codons 12, 13, and 61. Mutations at these positions result in reduced intrinsic GTPase activity and/or cause KRAS to become unresponsive to RasGAP.
    NRAS: 1 Assay
    The most important NRAS mutation in breast cancer occurs at codon 61.
    PIK3CA: 13 Assays
    The most frequently occurring PIK3CA mutations mainly belong to two classes: gain-of-function kinase domain activating mutations and helical domain mutations that mimic activation by growth factors.
    TP53: 56 Assays
    The most frequently detected somatic mutations in TP53 are largely composed of DNA-binding domain mutations which disrupt either DNA binding or protein structure.
    规格:84个位点/array    1sample/array
    灵敏度:可以检测低至0.1%的体细胞突变


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