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  • > 产品目录 > 科研产品 > 体细胞突变PCR芯片 > 卵巢癌体细胞突变PCR芯片
    人卵巢癌体细胞突变PCR芯片适用于快速、准确的进行卵巢癌相关基因突变的检测,包括:BRAF, CTNNB1/beta-catenin, ERBB2, FOXL2, GNAS, KIT, KRAS, NRAS, PIK3CA, PTEN和 p53。对上述基因突变的深入研究有助于科研工作者更好的了解肿瘤的发生机制,并为临床靶向用药提供可靠的分子机理。利用单个或多个体细胞突变信息检测关键信号通路异常已被广泛应用于临床研究。
    卵巢癌体细胞突变PCR芯片
    人卵巢癌体细胞突变PCR芯片适用于快速、准确的进行卵巢癌相关基因突变的检测,包括:BRAF, CTNNB1/beta-catenin, ERBB2, FOXL2, GNAS, KIT, KRAS, NRAS, PIK3CA, PTEN和 p53。对上述基因突变的深入研究有助于科研工作者更好的了解肿瘤的发生机制,并为临床靶向用药提供可靠的分子机理。利用单个或多个体细胞突变信息检测关键信号通路异常已被广泛应用于临床研究。例如: EGFR和KRAS基因突变能够预测靶向该位点的药物治疗响应。人卵巢癌体细胞突变PCR芯片覆盖广泛,适用于卵巢癌以及含有此类突变的其他肿瘤的突变检测,并有望为临床相关疾病提供潜在药物治疗靶点。该芯片包含83个卵巢癌中最常见的,具有重要功能和生理学意义的突变位点。突变位点主要由多种体细胞突变数据库以及经同行评阅的科学文献筛选得到,展示了超过2600例卵巢癌患者的最常见突变。
     
    Assay functional annotations
    BRAF: 1 Assay
    The most important BRAF mutation in ovarian cancer leads to increased kinase activity, the p. V600E mutation.
    CTNNB1: 9 Assays
    The most frequently detected CTNNB1/beta-catenin mutations result in abnormal signaling in the WNT signaling pathway. The mutated codons are mainly several serine/threonine residues targeted for phosphorylation by GSK-3beta.
    ERBB2: 2 Assays
    The most frequently identified ERBB2 activating mutations cluster in the ERBB2 kinase domain region.
    FOXL2: 1 Assay
    This mutation lies in wing 2 of the forkhead domain, a divergent component of the domain's secondary structure with unknown function, but the mutation does seem to inhibit the protein's pro-apoptotic function.
    GNAS: 1 Assay
    Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
    KIT: 3 Assays
    The most frequently identified KIT gain-of-function mutations include the D816V point mutation, the exon 11 (juxtamembrane domain) deletion and point mutations, an exon 9 insertion mutation, and exon 13 point mutations.
    KRAS: 10 Assays
    The mutation assays include the most frequently occurring mutations in KRAS codons 12, 13, and 61. Mutations at these positions result in reduced intrinsic GTPase activity and/or cause KRAS to become unresponsive to RasGAP.
    NRAS: 1 Assay
    The most important NRAS mutation in ovarian cancer occurs at codon 12.
    PIK3CA: 7 Assays
    The most frequently occurring PIK3CA mutations mainly belong to two classes: gain-of-function kinase domain activating mutations and helical domain mutations that mimic activation by growth factors.
    PTEN: 3 Assays
    The most commonly detected PTEN loss-of-function mutations are due to either truncation (p.R233* and p.R130*) or point mutations causing phosphatase inactivation (p.R130 and p.R173 mutations).
    TP53: 45 Assays
    The most frequently detected somatic mutations in TP53 are largely composed of DNA-binding domain mutations which disrupt either DNA binding or protein structure.
    规格:83个位点/array    1sample array 



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